Guyasuta probably served as scout for the young George Washington in 1753, although he played a role in the defeat of Braddock's expedition in 1755, and sided with the French in the French and Indian wars. Guyasuta was an important player in the Pontiac rebellion - indeed, some historians refer to this war as the Pontiac-Guyasuta war.
At the beginning of the American War of Independence, American revolutionaries tried to win Guyasuta to their cause, but like most Iroquois, he sided with the British, participating in the battle of Oriskany. After the war, Guyasuta tried to establish peaceful relations with the new United States.
Guyasuta is buried at Custaloga Town Scout Reservation, a Boy Scout camp located along French Creek, on the former site of Chief Custaloga Village in the French Creek Township, Pennsylvania.
In Pittsburgh, he is honored, with George Washington, in a large public sculpture called "Point of View," which overlooks Point State Park. In addition, the Laurel Highlands Scout Council of America has a camp property named in his honor. A statue of Guyasuta is located at the intersection of Main and North Canal streets in Sharpsburg, Pennsylvania.